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The American Medical Association (AMA) has made Current Procedural Terminology CPT® code changes to the 2021 edition of the CPT.
Diagnostic Laboratory of Oklahoma (DLO) will be implementing these changes effective January 1, 2021. Overall, the changes for 2021 AMA CPT coding affect the way we bill some of our tests. These tests may also be included in panels or profiles. The chart below lists some of the tests affected and the appropriate CPT code changes.
| DLO Order Code | DLO Test Name | 2020 CPT Coding | 2021 CPT Coding |
| 92476 | MPL Mutation Analysis | 81403 | 81339 |
| 92472 | JAK2 V617F Cascading Reflex to CALR, JAK2 Exon 12, MPL, and CSF3R | 81270 with reflex to CALR (calreticulin) (CPT code: 81219), then exon 12 of JAK2 (CPT code: 81403), then codon 505 and 515 of MPL (CPT code: 81403), and then two mutational hotspots in the CSF3R gene (CPT code: 81479) | 81270 with reflex to CALR (calreticulin) (CPT code: 81219), then exon 12 of JAK2 (CPT code: 81279), then codon 505 and 515 of MPL (CPT code: 81339), and then two mutational hotspots in the CSF3R gene (CPT code: 81479) |
| 92474 | JAK2 Exon 12 Mutation Analysis | 81403 | 81279 |
| 14991 | Mantle Cell Lymphona, BCL- 1/JH T(11.14) Cell Based | 81401 | 81168 |
| 15007 | Follicular Lymphoma bcl-2JH t(14 18) Real-time PCR Cell- based | 81402 | 81278 |
| 16515 | TP53 Somatic Mutation, Prognostic | 81405 | 81351 |
| 92560 | Li-Fraumeni Syndrome, TP53 Sequencing and Deletion/Duplication | 81405, 81479 | 81351, 81479 |
| 92587 | BRCAvantage® (BRCA1, BRCA2, TP53, PTEN, CDH1, STK11, PALB2) | 81162, 81307, 81321, 81323, 81404, 81405 (x2), 81406, 81479 | 81162, 81307, 81321, 81323, 81351, 81404, 81405, 81406, 81479 |
| 201 | Acetaminophen | 80299 | 80143 |
| 36721 | Amiodarone | 80299 | 80151 |
| 36676 | Carbamazepine- 10, 11 Epoxide, Serum/Plasma | 80156 | 80161 |
| 26513 | Carbamazepine and Metabolite, Total | 80156 | 80156, 80161 |
| 7933 | Carbamazepine and Metabolite, Free/Bound | 80156, 80157 | 80156, 80157, 80161 |
| 3081 | Felbamate | 80299 | 80167 |
| 5309 | Flecainide | 80299 | 80181 |
| 94092 | Itraconazole | 80299 | 80189 |
| 18865 | Leflunomide | 80299 | 80193 |
| 648 | Methotrexate | 80299 | 80204 |
| 16296 | Rufinamide | 80299 | 80210 |
| 805 | Salicylate | 80299 | 80179 |
| 36169 | Estradiol, Free | 82670 (x2) | 82670, 82681 |
We appreciate your support and look forward to continuing to serve all of your laboratory needs. DLO will make every effort to assist you with the transition to the 2021 AMA CPT coding being used for our test offerings.
Thank you very much for using DLO for your laboratory testing needs.
Note: The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
CLIA